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52-Week Top Gaining U.S. stocks

Track U.S. stocks with the strongest price gains over the past 52 weeks on MEXC. Stocks are ranked by their 52-week percentage change to highlight leading one-year performers.

52-Week Top Gaining U.S. stocks

Market Overview

U.S. stocks are mixed today. The Dow Jones is ⁦+0.09%⁩, the S&P 500 is ⁦-0.42%⁩, and the Nasdaq Composite is ⁦-0.91%⁩. Across individual stocks, 1,989 are advancing while 3,125 are declining, suggesting a mixed market tone.

Dow Jones
52,342.03
Change
+44.94+0.09%
S&P 500
7,560.87
Change
-31.53-0.42%
Nasdaq Composite
25,135.961
Change
-230.132-0.91%
24H Gainers
1,989
24H Losers
3,125

52 Week Gainers

#Stock52 Week Range
4351Optimi Health Corp.OPTH$2.27-3.67%39.98K$12.97M$1.90 - $6.400.00%
4352Beam GlobalBEEM$0.67-0.69%154.43K$15.21M$0.65 - $2.310.00%
4353DeFi Development Corp.DFDV$3.03+2.88%1.47M$120.42M$2.44 - $8.710.00%
4354Skyline Builders Group Holding LimitedKAZR$1.19-7.20%164.58K$22.43M$0.92 - $3.390.00%
4355Obsidian Therapeutics, Inc.OBX$12.58+0.80%254.69K$795.63M$9.60 - $49.970.00%
4356Solidion Technology, Inc.STI$3.74-3.13%54.18K$33.63M$2.94 - $46.000.00%
4357Seritage Growth PropertiesSRG$1.51-1.30%56.12K$85.33M$1.50 - $4.200.06%
4358Rezolute, Inc.RZLT$3.65-5.68%5.53M$352.77M$1.07 - $11.160.00%
4359The Trade Desk, Inc.TTD$15.68+0.78%12.83M$6.74B$11.62 - $43.860.00%
4360AIOS Tech Inc.AIOS$8.05+2.56%2.41K$26.15M$6.54 - $33.870.00%
4361Stewards, Inc.SWRD$2.56+4.86%363.93K$540.54M$1.46 - $7.500.00%
4362Peraso, Inc.PRSO$0.31-16.19%788.07K$4.69M$0.28 - $2.160.00%
4363Metalpha Technology Holding LimitedMATH$1.03+6.08%33.21K$48.96M$0.73 - $3.190.00%
4364Kyntra Bio, Inc.KYNB$3.47+0.28%13.68K$14.05M$3.35 - $9.700.00%
4365Atlas Lithium CorporationATLX$1.55-4.05%179.44K$45.86M$1.51 - $6.720.00%
4366Workhorse Group, Inc.WKHS$2.88-4.97%183.91K$31.47M$2.31 - $12.960.00%
4367Alnylam Pharmaceuticals, Inc.ALNY$165.03+5.34%3.05M$22.10B$149.18 - $479.790.00%
4368Waton Financial LimitedWTF$2.06+0.75%7.31K$101.78M$1.76 - $6.330.00%
4369Sound Point Meridian Capital, Inc.SPMC$6.03-4.48%44.11K$123.68M$5.43 - $16.670.00%
4370MNTN, Inc.MNTN$5.05+1.00%1.40M$377.43M$4.60 - $14.340.00%
4371Dyadic International, Inc.DYAI$0.33-5.28%188.16K$13.10M$0.32 - $1.600.00%
4372Stellantis N.V.STLA$3.83-0.91%34.14M$11.94B$3.83 - $12.220.00%
4373GEN Restaurant Group, Inc.GENK$0.96+3.08%67.29K$7.01M$0.92 - $2.850.00%
4374Fiverr International Ltd.FVRR$8.04+1.26%682.21K$289.22M$7.80 - $22.380.00%
4375GrabAGun Digital Holdings Inc.PEW$1.50-13.20%970.71K$53.42M$1.49 - $4.290.00%
4376Aprea Therapeutics, Inc.APRE$0.43-9.51%86.11K$6.07M$0.37 - $1.490.00%
4377Gloo Holdings, Inc.GLOO$2.91-2.68%105.18K$283.75M$2.60 - $9.980.00%
4378REalloys Inc.ALOY$5.71-9.57%2.52M$397.52M$5.45 - $26.900.00%
4379Cadeler plcCDLR$6.63-4.04%324.63K$2.34B$6.44 - $32.810.00%
4380Vulcan Infrastructure and Power Inc.VIP$0.87-7.65%80.09K$13.70M$0.85 - $2.790.00%
4381Longeveron Inc.LGVN$2.45-16.50%59.18K$7.46M$1.31 - $12.300.00%
4382Solana CompanyHSDT$1.75-7.94%449.69K$105.98M$1.19 - $5.110.00%
4383FBS Global LimitedFBGL$2.16-2.75%2.27K$3.19M$2.00 - $14.000.00%
4384HomesToLife LtdHTLM$1.07-2.73%15.91K$95.97M$1.00 - $4.190.00%
4385Solarmax Technology Inc.SMXT$4.14-2.24%2.10K$19.66M$1.82 - $15.240.00%
4386Pyxis Oncology, Inc.PYXS$1.57+0.32%315.42K$188.34M$1.03 - $5.550.00%
4387Gain Therapeutics, Inc.GANX$1.05-3.70%312.10K$45.78M$0.94 - $4.340.00%
4388InspireMD, Inc.NSPR$0.66-15.12%1.29M$30.50M$0.43 - $2.220.00%
4389Alphatec Holdings, Inc.ATEC$7.07+0.14%2.33M$1.10B$6.81 - $23.290.00%
4390Cerebras Systems Inc.CBRS$108.69+9.78%35.17M$24.01B$77.84 - $386.340.00%
4391Briacell Therapeutics Corp.BCTX$3.40-4.56%25.11K$29.69M$2.60 - $13.090.00%
4392Aligos Therapeutics, Inc.ALGS$2.11+6.31%56.13K$13.18M$1.92 - $13.690.00%
4393Mustang Bio, Inc.MBIO$0.42-3.98%19.46K$2.83M$0.35 - $1.430.00%
4394Canton Strategic Holdings, Inc.CNTN$1.72-4.72%423.21K$136.65M$1.66 - $5.260.00%
4395Inseego Corp.INSG$4.02-9.80%196.45K$66.06M$3.58 - $21.900.00%
4396Mineralys Therapeutics, Inc.MLYS$15.33-1.06%1.11M$1.36B$14.80 - $47.000.00%
4397BTC Digital Ltd.BTCT$0.64+7.80%333.77K$10.81M$0.43 - $2.750.00%
4398Solo Brands, Inc.SBDS$0.000.00%0$0$1.40 - $12.360.00%
4399MicroCloud Hologram Inc.HOLO$1.19-4.07%144.56K$16.79M$0.88 - $3.900.00%
4400Canadian Solar Inc.CSIQ$9.87-1.79%1.29M$670.21M$8.79 - $34.590.00%

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Frequently Asked Questions (FAQ)

What are 52-week top gaining U.S. stocks?
These are U.S. stocks with some of the strongest price gains over the past 52 weeks, providing a view of longer-term stock performance.
How is the 52-week gain calculated?
It compares a stock's latest available price with its price roughly 52 weeks earlier and expresses the change as a percentage.
Which stock has gained the most over 52 weeks?
Optimi Health Corp. (OPTH) currently leads with a 52-week gain of 62.73% as of 2026-11-13 22:39 UTC.
Why use a 52-week stock performance ranking?
It helps users identify stocks with sustained price strength over a longer period rather than focusing only on daily market moves.
Does strong 52-week performance guarantee future gains?
No. Historical stock performance does not determine future returns and should be considered alongside company fundamentals and current market conditions.
How is this different from the daily Top Gainers list?
The 52-week ranking focuses on one-year performance, while Top Gainers highlights shorter-term price movements.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.